Version 5.4
Mus musculus Gene: Lphn1
Summary
InnateDB Gene IDBG-172817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lphn1
Gene Name latrophilin 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000013033
Encoded Proteins
IDBP-172821
latrophilin 1
IDBP-542027
latrophilin 1
IDBP-535120
latrophilin 1
IDBP-541606
latrophilin 1
IDBP-541785
latrophilin 1
IDBP-536698
latrophilin 1
IDBP-538232
latrophilin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072071:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:83900105-83941954
Strand Forward strand
Band C2
Transcripts
ENSMUST00000045393 ENSMUSP00000048422
ENSMUST00000141158 ENSMUSP00000118452
ENSMUST00000124355 ENSMUSP00000116064
ENSMUST00000132500 ENSMUSP00000119100
ENSMUST00000152978 ENSMUSP00000115295
ENSMUST00000139575
ENSMUST00000131717 ENSMUSP00000118579
ENSMUST00000150674
ENSMUST00000141661
ENSMUST00000131018 ENSMUSP00000117720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016524 latrotoxin receptor activity
GO:0030246 carbohydrate binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007157 heterophilic cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0090129 positive regulation of synapse maturation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030426 growth cone
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000072071
View Gene Order
ENSBTAG00000003675
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260733
RefSeq NM_181039 XM_006531120 XM_006531121 XM_006531122 XM_006531125 XM_006531126 XM_006531127 XM_006531128
OMIM
CCDS CCDS52613
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca