InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF4EBP1

Summary

InnateDB Gene

IDBG-17284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF4EBP1

Gene Name

eukaryotic translation initiation factor 4E binding protein 1

Synonyms

4E-BP1; 4EBP1; BP-1; PHAS-I

Species

Homo sapiens

Ensembl Gene

ENSG00000187840

Encoded Proteins

IDBP-17286

eukaryotic translation initiation factor 4E binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25531441

[Mus musculus] Genetic deletion of Eif4ebp1 or Eif4ebp2 potentiates innate antiviral immunity by enhancing translation of Irf7.

Entrez Gene

Summary

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5\' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:38030341-38060365

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000338825	ENSP00000340691
ENST00000520657

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008190	eukaryotic initiation factor 4E binding
GO:0030371	translation repressor activity
GO:0031369	translation initiation factor binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0002931	response to ischemia
GO:0006412	translation
GO:0006413	translational initiation
GO:0008286	insulin receptor signaling pathway
GO:0010467	gene expression
GO:0030324	lung development
GO:0031333	negative regulation of protein complex assembly
GO:0031929	TOR signaling
GO:0044267	cellular protein metabolic process
GO:0045471	response to ethanol
GO:0045931	positive regulation of mitotic cell cycle
GO:0045947	negative regulation of translational initiation