Version 5.4
Mus musculus Gene: Ctss
Summary
InnateDB Gene IDBG-172850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctss
Gene Name cathepsin S
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038642
Encoded Proteins
IDBP-172852
cathepsin S
IDBP-274449
cathepsin S
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21145045
Ctss is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctss in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 18762176
[Homo sapiens] CTSS is a member of the Cathepsins protein family, which are key modulators of cell death and inflammatory responses.
PMID 21145045
[Homo sapiens] CTSS is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSS in macrophages. (Demonstrated in murine model)
PMID 25884905
[Homo sapiens] Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163131:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:95526786-95556403
Strand Forward strand
Band F2.1
Transcripts
ENSMUST00000015667 ENSMUSP00000015667
ENSMUST00000116304 ENSMUSP00000112006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
Biological Process
GO:0002250 adaptive immune response
GO:0006508 proteolysis
GO:0030574 collagen catabolic process
GO:0034769 basement membrane disassembly
GO:0045087 innate immune response (InnateDB)
GO:0050729 positive regulation of inflammatory response
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0097067 cellular response to thyroid hormone stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0016020 membrane
GO:0031905 early endosome lumen
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163131
View Gene Order
ENSBTAG00000017135
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_239142
Innate Immune System pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_198976
Trafficking and processing of endosomal TLR pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_199112
Endosomal/Vacuolar pathway pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_229531
Adaptive Immune System pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
mmu04612
Antigen processing and presentation pathway
mmu04142
Lysosome pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111168
Endosomal/Vacuolar pathway pathway
REACT_118632
Trafficking and processing of endosomal TLR pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_118779
Extracellular matrix organization pathway
REACT_6802
Innate Immune System pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_120729
Collagen formation pathway
REACT_206550
Collagen formation pathway
REACT_223425
Extracellular matrix organization pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_225126
Trafficking and processing of endosomal TLR pathway
REACT_213138
Immune System pathway
REACT_201925
Degradation of the extracellular matrix pathway
REACT_226104
Assembly of collagen fibrils and other multimeric structures pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_220927
Endosomal/Vacuolar pathway pathway
REACT_214469
Adaptive Immune System pathway
REACT_216714
Innate Immune System pathway
REACT_218645
Antigen processing-Cross presentation pathway
KEGG
hsa04612
Antigen processing and presentation pathway
hsa04142
Lysosome pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt O70370
TrEMBL F6WR04 Q3UBR4 Q3UD32 Q8BSZ5
UniProt Splice Variant
Entrez Gene 13040
UniGene Mm.3619 Mm.402416
RefSeq NM_001267695 NM_021281 XM_006500975
OMIM
CCDS CCDS50992 CCDS71291
HPRD
IMGT
MGI ID MGI:107341
MGI Symbol Ctss
EMBL AC092203 AF038546 AF051726 AF051727 AF051728 AF051729 AF051730 AF051731 AF051732 AJ002386 AJ223208 AK028366 AK150274 AK150758 AK150842 AK152618 CH466620 Y18466
GenPept AAB94925 AAC05781 BAC25906 BAE29430 BAE29827 BAE29900 BAE31361 CAA05360 CAA11182 CAA77184 EDL38819
RNA Seq Atlas 13040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca