Version 5.4
Mus musculus Gene: Tbca
Summary
InnateDB Gene IDBG-173482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbca
Gene Name tubulin cofactor A
Synonyms Tbca13
Species Mus musculus
Ensembl Gene ENSMUSG00000042043
Encoded Proteins
IDBP-173484
tubulin cofactor A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171530:
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. [provided by RefSeq, Jul 2008]
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:94788943-94842899
Strand Forward strand
Band D1
Transcripts
ENSMUST00000046644 ENSMUSP00000038781
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051082 unfolded protein binding
Biological Process
GO:0007021 tubulin complex assembly
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005874 microtubule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171530
View Gene Order
ENSBTAG00000003263
Not yet available
Pathways
NETPATH
REACTOME
REACT_247926
Metabolism of proteins pathway
REACT_247933
Post-chaperonin tubulin folding pathway pathway
REACT_245534
Protein folding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16967
Post-chaperonin tubulin folding pathway pathway
REACT_16952
Protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_215959
Post-chaperonin tubulin folding pathway pathway
REACT_213782
Metabolism of proteins pathway
REACT_215927
Protein folding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P48428
TrEMBL Q5I0U7
UniProt Splice Variant
Entrez Gene 21371
UniGene Mm.310036 Mm.465399
RefSeq NM_009321
OMIM
CCDS CCDS26694
HPRD
IMGT
MGI ID MGI:107549
MGI Symbol Tbca
EMBL AK010859 AK140276 AK151218 AK168296 BC034267 BC051475 BC055749 BC087931 CH466567 U05333
GenPept AAA83250 AAH34267 AAH51475 AAH55749 AAH87931 BAB27228 BAE24312 BAE30212 BAE40239 EDL00918
RNA Seq Atlas 21371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca