Version 5.4
Mus musculus Gene: Klc1
Summary
InnateDB Gene IDBG-173552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klc1
Gene Name kinesin light chain 1
Synonyms AI874768; Kns2
Species Mus musculus
Ensembl Gene ENSMUSG00000021288
Encoded Proteins
IDBP-173562
kinesin light chain 1
IDBP-401034
kinesin light chain 1
IDBP-401033
kinesin light chain 1
IDBP-401032
kinesin light chain 1
IDBP-531757
kinesin light chain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:111758849-111807844
Strand Forward strand
Band F1
Transcripts
ENSMUST00000084941 ENSMUSP00000082004
ENSMUST00000122300 ENSMUSP00000113997
ENSMUST00000118471 ENSMUSP00000113171
ENSMUST00000120544 ENSMUSP00000113237
ENSMUST00000134578 ENSMUSP00000120491
ENSMUST00000140792
ENSMUST00000124197
ENSMUST00000141435
ENSMUST00000147203
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0015631 tubulin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0008088 axon cargo transport
GO:0008152 metabolic process
GO:0035418 protein localization to synapse
Cellular Component
GO:0005737 cytoplasm
GO:0005871 kinesin complex
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0035253 ciliary rootlet
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043227 membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126214
View Gene Order
ENSBTAG00000017299
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_25201
Kinesins pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.427601
RefSeq NM_001025359 NM_001025360 NM_001025362 NM_001081959 NM_008450 XM_006515493
OMIM
CCDS CCDS36565 CCDS49182 CCDS49183 CCDS70423
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca