Version 5.4
Mus musculus Gene: Irs1
Summary
InnateDB Gene IDBG-173589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irs1
Gene Name insulin receptor substrate 1
Synonyms G972R; IRS-1
Species Mus musculus
Ensembl Gene ENSMUSG00000055980
Encoded Proteins
IDBP-173591
insulin receptor substrate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169047:
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:82233101-82291416
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000069799 ENSMUSP00000063795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 55 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016042 lipid catabolic process
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0034504 protein localization to nucleus
GO:0043491 protein kinase B signaling
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:2001275 positive regulation of glucose import in response to insulin stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169047
View Gene Order
ENSBTAG00000021308
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04930
Type II diabetes mellitus pathway
mmu04910
Insulin signaling pathway pathway
mmu04150
mTOR signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_9
TNFalpha pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_16
IL4 pathway
NetPath_19
IL-7 pathway
NetPath_20
IL9 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_111133
Growth hormone receptor signaling pathway
REACT_12464
PI3K/AKT activation pathway
REACT_524
SOS-mediated signalling pathway
REACT_508
Signal attenuation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_570
IRS activation pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
INOH website
IL-13 signaling pathway
INOH website
Insulin receptor signaling pathway
INOH website
IGF1 signaling pathway pathway
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
s1p_s1p2_pathway
S1P2 pathway
ptp1bpathway
Signaling events mediated by PTP1B
mtor_4pathway
mTOR signaling pathway
igf1_pathway
IGF1 pathway
il4_2pathway
IL4-mediated signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
shp2_pathway
SHP2 signaling
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.426987 Mm.428883 Mm.429405 Mm.448079 Mm.4952
RefSeq NM_010570 XM_006496441
OMIM
CCDS CCDS15096
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca