Version 5.4
Mus musculus Gene: Pcsk4
Summary
InnateDB Gene IDBG-173664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcsk4
Gene Name proprotein convertase subtilisin/kexin type 4
Synonyms AI647044; L21221; NEC 3; NEC3; PC4; SPC5
Species Mus musculus
Ensembl Gene ENSMUSG00000020131
Encoded Proteins
IDBP-173666
proprotein convertase subtilisin/kexin type 4
IDBP-711513
IDBP-711249
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115257:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein (proPACAP) and pro-insulin-like growth factor II. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80321283-80329498
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000020340 ENSMUSP00000020340
ENSMUST00000128653 ENSMUSP00000137809
ENSMUST00000137177
ENSMUST00000147132
ENSMUST00000130521
ENSMUST00000135071 ENSMUSP00000137719
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0009566 fertilization
GO:0048240 sperm capacitation
Cellular Component
GO:0002080 acrosomal membrane
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115257
View Gene Order
ENSBTAG00000002305
Not yet available
Pathways
NETPATH
REACTOME
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_206713
NGF processing pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P29121
TrEMBL
UniProt Splice Variant
Entrez Gene 18551
UniGene Mm.299916
RefSeq NM_008793
OMIM
CCDS CCDS24018
HPRD
IMGT
MGI ID MGI:97514
MGI Symbol Pcsk4
EMBL D01093 L21210 L21211 L21212 L21213 L21214 L21215 L21216 L21217 L21218 L21219 L21220 L21221 L21222 L21223
GenPept AAA39973 BAA00877
RNA Seq Atlas 18551

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca