InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xrcc3

Summary

InnateDB Gene

IDBG-173748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrcc3

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 3

Synonyms

4432412E01Rik; AI182522; AW537713

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021287

Encoded Proteins

IDBP-173750

X-ray repair complementing defective repair in Chinese hamster cells 3

IDBP-540811

X-ray repair complementing defective repair in Chinese hamster cells 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126215:
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:111803192-111813873

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021715	ENSMUSP00000021715
ENSMUST00000127281	ENSMUSP00000118040
ENSMUST00000124064
ENSMUST00000146491
ENSMUST00000145109
ENSMUST00000132177
ENSMUST00000129258
ENSMUST00000133679

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0008821	crossover junction endodeoxyribonuclease activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0010033	response to organic substance
GO:0010824	regulation of centrosome duplication
GO:0071140	resolution of mitotic recombination intermediates
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint

Cellular Component

GO:0005634	nucleus
GO:0005657	replication fork
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0033065	Rad51C-XRCC3 complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000126215

View Gene Order

ENSBTAG00000009966

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03440

Homologous recombination pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03440

Homologous recombination pathway

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.19082

RefSeq

NM_028875 XM_006516299

OMIM

CCDS

CCDS26187

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas