Version 5.4
Homo sapiens Gene: MOAP1
Summary
InnateDB Gene IDBG-17380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MOAP1
Gene Name modulator of apoptosis 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165943
Encoded Proteins
IDBP-17382
modulator of apoptosis 1
IDBP-595308
modulator of apoptosis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:93182196-93184928
Strand Reverse strand
Band q32.12
Transcripts
ENST00000298894 ENSP00000298894
ENST00000556883 ENSP00000451594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000096458
View Gene Order
Cross-References
SwissProt Q96BY2
TrEMBL
UniProt Splice Variant
Entrez Gene 64112
UniGene Hs.24719
RefSeq NM_022151
HUGO HGNC:16658
OMIM 609485
CCDS CCDS9908
HPRD
IMGT
EMBL AF305550 AK024029 AK315522 BC015044 CH471061
GenPept AAG31786 AAH15044 BAB14788 BAG37903 EAW81516
RNA Seq Atlas 64112

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca