Version 5.4
Homo sapiens Gene: STAR
Summary
InnateDB Gene IDBG-17383.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAR
Gene Name steroidogenic acute regulatory protein
Synonyms STARD1
Species Homo sapiens
Ensembl Gene ENSG00000147465
Encoded Proteins
IDBP-17385
steroidogenic acute regulatory protein
IDBP-478876
steroidogenic acute regulatory protein
IDBP-478442
steroidogenic acute regulatory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:38143649-38151265
Strand Reverse strand
Band p11.23
Transcripts
ENST00000276449 ENSP00000276449
ENST00000520114
ENST00000522050 ENSP00000429009
ENST00000521236 ENSP00000430030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
Biological Process
GO:0006082 organic acid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006699 bile acid biosynthetic process
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0007623 circadian rhythm
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0008584 male gonad development
GO:0009635 response to herbicide
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010212 response to ionizing radiation
GO:0010288 response to lead ion
GO:0010628 positive regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0014823 response to activity
GO:0016101 diterpenoid metabolic process
GO:0017085 response to insecticide
GO:0017143 insecticide metabolic process
GO:0018879 biphenyl metabolic process
GO:0018894 dibenzo-p-dioxin metabolic process
GO:0018958 phenol-containing compound metabolic process
GO:0018963 phthalate metabolic process
GO:0031667 response to nutrient levels
GO:0032367 intracellular cholesterol transport
GO:0032869 cellular response to insulin stimulus
GO:0034698 response to gonadotropin
GO:0035094 response to nicotine
GO:0035457 cellular response to interferon-alpha
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042747 circadian sleep/wake cycle, REM sleep
GO:0043434 response to peptide hormone
GO:0043524 negative regulation of neuron apoptotic process
GO:0043627 response to estrogen
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0044321 response to leptin
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045471 response to ethanol
GO:0046677 response to antibiotic
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048545 response to steroid hormone
GO:0050756 fractalkine metabolic process
GO:0050769 positive regulation of neurogenesis
GO:0050810 regulation of steroid biosynthetic process
GO:0051412 response to corticosterone
GO:0060992 response to fungicide
GO:0061370 testosterone biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071236 cellular response to antibiotic
GO:0071248 cellular response to metal ion
GO:0071276 cellular response to cadmium ion
GO:0071312 cellular response to alkaloid
GO:0071320 cellular response to cAMP
GO:0071333 cellular response to glucose stimulus
GO:0071346 cellular response to interferon-gamma
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071373 cellular response to luteinizing hormone stimulus
GO:0071378 cellular response to growth hormone stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071872 cellular response to epinephrine stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0030061 mitochondrial crista
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031574
View Gene Order
ENSBTAG00000033345
Not yet available
Pathways
NETPATH
REACTOME
REACT_11038
Pregnenolone biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.521535
RefSeq NM_000349
HUGO
OMIM
CCDS CCDS6102
HPRD 02794
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca