InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PSPH

Summary

InnateDB Gene

IDBG-17389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSPH

Gene Name

phosphoserine phosphatase

Synonyms

PSP; PSPHD

Species

Homo sapiens

Ensembl Gene

ENSG00000146733

Encoded Proteins

IDBP-17391

phosphoserine phosphatase

IDBP-239479

phosphoserine phosphatase

IDBP-375964

phosphoserine phosphatase

IDBP-375971

phosphoserine phosphatase

IDBP-375972

phosphoserine phosphatase

IDBP-375975

phosphoserine phosphatase

IDBP-375977

phosphoserine phosphatase

IDBP-375978

phosphoserine phosphatase

IDBP-375983

phosphoserine phosphatase

IDBP-375985

phosphoserine phosphatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:56011051-56051604

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000275605	ENSP00000275605
ENST00000395471	ENSP00000378854
ENST00000437355	ENSP00000401639
ENST00000421626	ENSP00000398653
ENST00000427797	ENSP00000403431
ENST00000419984	ENSP00000399660
ENST00000421312	ENSP00000390952
ENST00000424596	ENSP00000390452
ENST00000416592	ENSP00000405538
ENST00000413218	ENSP00000404674
ENST00000459834
ENST00000472276

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004647	phosphoserine phosphatase activity
GO:0005509	calcium ion binding
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0008152	metabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009612	response to mechanical stimulus
GO:0016311	dephosphorylation
GO:0031667	response to nutrient levels
GO:0033574	response to testosterone
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043005	neuron projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029446

View Gene Order

ENSBTAG00000013081

Not yet available

Pathways

NETPATH

REACTOME

REACT_115789

Serine biosynthesis pathway

REACT_238

Amino acid synthesis and interconversion (transamination) pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00260

Glycine, serine and threonine metabolism pathway

INOH

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.512656

RefSeq

NM_004577 XM_005271773 XM_005271775

HUGO

OMIM

CCDS

CCDS5522

HPRD

01406

IMGT

EMBL

GenPept

RNA Seq Atlas