InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dpp4

Summary

InnateDB Gene

IDBG-173968.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpp4

Gene Name

dipeptidylpeptidase 4

Synonyms

Cd26; Dpp-4; THAM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035000

Encoded Proteins

IDBP-173972

dipeptidylpeptidase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197635:
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:62330073-62412231

Strand

Reverse strand

Band

C1.3

Transcripts

ENSMUST00000047812	ENSMUSP00000044050
ENSMUST00000156871
ENSMUST00000129738
ENSMUST00000150979
ENSMUST00000149306
ENSMUST00000151818

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004177	aminopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0008284	positive regulation of cell proliferation
GO:0010716	negative regulation of extracellular matrix disassembly
GO:0031295	T cell costimulation
GO:0033632	regulation of cell-cell adhesion mediated by integrin
GO:0042110	T cell activation
GO:0043542	endothelial cell migration

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0031258	lamellipodium membrane
GO:0045121	membrane raft
GO:0046581	intercellular canaliculus
GO:0070062	extracellular vesicular exosome
GO:0071438	invadopodium membrane