Version 5.4
Mus musculus Gene: Tnip1
Summary
InnateDB Gene IDBG-174207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnip1
Gene Name TNFAIP3 interacting protein 1
Synonyms ABIN; ABIN-1; ABIN1; AU018810; Naf1; Nef; VAN
Species Mus musculus
Ensembl Gene ENSMUSG00000020400
Encoded Proteins
IDBP-174211
TNFAIP3 interacting protein 1
IDBP-174213
TNFAIP3 interacting protein 1
IDBP-174215
TNFAIP3 interacting protein 1
IDBP-263576
TNFAIP3 interacting protein 1
IDBP-263578
TNFAIP3 interacting protein 1
IDBP-263580
TNFAIP3 interacting protein 1
IDBP-539589
TNFAIP3 interacting protein 1
IDBP-531910
TNFAIP3 interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21606507
Tnip1 interacts with polyubiquitin to limit the activation of Tlr-Myd88 signalling pathway and prevents autoimmunity.
PMID 22011580
Tnip1 is an essential anti-inflammatory component of TLR-signalling pathways that controls Cebpb activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease.
InnateDB Annotation from Orthologs
Summary
PMID 21606507
[Homo sapiens] TNIP1 interacts with polyubiquitin to limit the activation of TLR-MYD88 signalling pathway and prevents autoimmunity. (Demonstrated in murine model)
PMID 22011580
[Homo sapiens] TNIP1 is an essential anti-inflammatory component of TLR-signalling pathways that controls CEBPB activity. Tnip1 null mice exhibit progressive, lupus-like inflammatory disease. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145901:
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:54910785-54962917
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000018482 ENSMUSP00000018482
ENSMUST00000102731 ENSMUSP00000099792
ENSMUST00000102730 ENSMUSP00000099791
ENSMUST00000108889 ENSMUSP00000104517
ENSMUST00000108886 ENSMUSP00000104514
ENSMUST00000108885 ENSMUSP00000104513
ENSMUST00000124304
ENSMUST00000132224
ENSMUST00000126703 ENSMUSP00000122836
ENSMUST00000155316 ENSMUSP00000116721
ENSMUST00000151736
ENSMUST00000132776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005488 binding
GO:0005515 protein binding
GO:0031593 polyubiquitin binding
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0007159 leukocyte cell-cell adhesion
GO:0008152 metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050729 positive regulation of inflammatory response
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0085032 modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145901
View Gene Order
ENSBTAG00000012671
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.259671
RefSeq NM_001199275 NM_001199276 NM_001271455 NM_001271456 NM_021327 XM_006533846 XM_006533847 XM_006533848
OMIM
CCDS CCDS24704 CCDS56769 CCDS70188
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca