InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccl20

Summary

InnateDB Gene

IDBG-174322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl20

Gene Name

chemokine (C-C motif) ligand 20

Synonyms

CKb4; exodus-1; LARC; MIP-3[a]; MIP-3A; MIP3A; Scya20; ST38

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026166

Encoded Proteins

IDBP-174324

chemokine (C-C motif) ligand 20

IDBP-253878

chemokine (C-C motif) ligand 20

IDBP-790260

chemokine (C-C motif) ligand 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115009:
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:83116766-83119167

Strand

Forward strand

Band

Transcripts

ENSMUST00000027351	ENSMUSP00000027351
ENSMUST00000113437	ENSMUSP00000109064
ENSMUST00000186832	ENSMUSP00000139923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0042060	wound healing
GO:0042466	chemokinesis
GO:0050726	positive regulation of interleukin-1 alpha biosynthetic process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0071310	cellular response to organic substance
GO:2000406	positive regulation of T cell migration