Version 5.4
Mus musculus Gene: Anxa6
Summary
InnateDB Gene IDBG-174493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anxa6
Gene Name annexin A6
Synonyms Anx6; AnxVI; AW107198; Cabm; Camb
Species Mus musculus
Ensembl Gene ENSMUSG00000018340
Encoded Proteins
IDBP-174497
annexin A6
IDBP-263590
annexin A6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197043:
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:54979108-55033445
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000102727 ENSMUSP00000099788
ENSMUST00000108883 ENSMUSP00000104511
ENSMUST00000148298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008289 lipid binding
GO:0015276 ligand-gated ion channel activity
GO:0015485 cholesterol binding
GO:0042803 protein homodimerization activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0006816 calcium ion transport
GO:0006937 regulation of muscle contraction
GO:0034220 ion transmembrane transport
GO:0051260 protein homooligomerization
Cellular Component
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0042470 melanosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197043
View Gene Order
ENSBTAG00000014809
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.265347
RefSeq NM_001110211 NM_013472
OMIM
CCDS CCDS24705 CCDS48799
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca