InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clu

Summary

InnateDB Gene

IDBG-174736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clu

Gene Name

clusterin

Synonyms

AI893575; ApoJ; Cli; D14Ucla3; Sgp-2; Sgp2; SP-40; Sugp-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022037

Encoded Proteins

IDBP-174738

clusterin

IDBP-538382

clusterin

IDBP-532306

clusterin

IDBP-542694

clusterin

IDBP-534831

clusterin

IDBP-536274

clusterin

IDBP-540066

clusterin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:65968483-65981548

Strand

Forward strand

Band

Transcripts

ENSMUST00000022616	ENSMUSP00000022616
ENSMUST00000138665	ENSMUSP00000121056
ENSMUST00000146990
ENSMUST00000153460	ENSMUSP00000121633
ENSMUST00000127387	ENSMUSP00000114720
ENSMUST00000138191	ENSMUSP00000117555
ENSMUST00000128539	ENSMUSP00000121485
ENSMUST00000144619	ENSMUSP00000117953
ENSMUST00000152903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0051787	misfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001774	microglial cell activation
GO:0008219	cell death
GO:0009615	response to virus
GO:0017038	protein import
GO:0032286	central nervous system myelin maintenance
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463	negative regulation of protein homooligomerization
GO:0032760	positive regulation of tumor necrosis factor production
GO:0043065	positive regulation of apoptotic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050821	protein stabilization
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051131	chaperone-mediated protein complex assembly
GO:0051788	response to misfolded protein
GO:0061077	chaperone-mediated protein folding
GO:0061518	microglial cell proliferation
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900221	regulation of beta-amyloid clearance
GO:1901214	regulation of neuron death
GO:1901216	positive regulation of neuron death
GO:1902004	positive regulation of beta-amyloid formation
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430	negative regulation of beta-amyloid formation
GO:1902847	regulation of neuronal signal transduction
GO:1902949	positive regulation of tau-protein kinase activity
GO:1902998	positive regulation of neurofibrillary tangle assembly
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0031012	extracellular matrix
GO:0031966	mitochondrial membrane
GO:0034366	spherical high-density lipoprotein particle
GO:0042583	chromaffin granule
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle
GO:0097418	neurofibrillary tangle
GO:0097440	apical dendrite