InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P2RX5

Summary

InnateDB Gene

IDBG-17474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX5

Gene Name

purinergic receptor P2X, ligand-gated ion channel, 5

Synonyms

LRH-1; P2X5; P2X5R

Species

Homo sapiens

Ensembl Gene

ENSG00000083454

Encoded Proteins

IDBP-17486

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-17488

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-597562

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-594293

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-597210

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-588802

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-600125

purinergic receptor P2X, ligand-gated ion channel, 5

IDBP-762241

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:3672199-3696404

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000225328	ENSP00000225328
ENST00000345901	ENSP00000342161
ENST00000551178	ENSP00000447545
ENST00000547178	ENSP00000448355
ENST00000549063
ENST00000552456	ENSP00000447815
ENST00000552050	ENSP00000450006
ENST00000552723	ENSP00000449495
ENST00000550772
ENST00000547933
ENST00000552276	ENSP00000467707

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005524	ATP binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0050850	positive regulation of calcium-mediated signaling

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005950

View Gene Order

ENSBTAG00000015258

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001204519 NM_001204520 NM_002561 NM_175080

HUGO

OMIM

CCDS

CCDS11034 CCDS11035 CCDS56014 CCDS56015

HPRD

09110

IMGT

EMBL

GenPept

RNA Seq Atlas