Version 5.4
Homo sapiens Gene: SCT
Summary
InnateDB Gene IDBG-17495.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCT
Gene Name secretin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070031
Encoded Proteins
IDBP-17497
secretin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:626431-627143
Strand Reverse strand
Band p15.5
Transcripts
ENST00000176195 ENSP00000176195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0008542 visual learning
GO:0021542 dentate gyrus development
GO:0030157 pancreatic juice secretion
GO:0043524 negative regulation of neuron apoptotic process
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000038580
View Gene Order
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P09683
TrEMBL
UniProt Splice Variant
Entrez Gene 6343
UniGene Hs.632324
RefSeq NM_021920
HUGO HGNC:10607
OMIM 182099
CCDS CCDS7709
HPRD
IMGT
EMBL AF244355
GenPept AAG31443
RNA Seq Atlas 6343

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca