InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TBXA2R

Summary

InnateDB Gene

IDBG-17506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBXA2R

Gene Name

thromboxane A2 receptor

Synonyms

BDPLT13; TXA2-R

Species

Homo sapiens

Ensembl Gene

ENSG00000006638

Encoded Proteins

IDBP-79929

thromboxane A2 receptor

IDBP-364350

thromboxane A2 receptor

IDBP-761355

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3594506-3606840

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000375190	ENSP00000364336
ENST00000411851	ENSP00000393333
ENST00000587717
ENST00000589966	ENSP00000468145

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.

Experimentally validated
Total	60 [view]
Protein-Protein	57 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004960	thromboxane receptor activity
GO:0004961	thromboxane A2 receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0019229	regulation of vasoconstriction
GO:0019932	second-messenger-mediated signaling
GO:0030168	platelet activation
GO:0032496	response to lipopolysaccharide
GO:0038193	thromboxane A2 signaling pathway
GO:0042493	response to drug
GO:0043547	positive regulation of GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0045777	positive regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction