Version 5.4
Mus musculus Gene: Gfm2
Summary
InnateDB Gene IDBG-175066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gfm2
Gene Name G elongation factor, mitochondrial 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021666
Encoded Proteins
IDBP-175068
G elongation factor, mitochondrial 2
IDBP-175070
G elongation factor, mitochondrial 2
IDBP-534082
G elongation factor, mitochondrial 2
IDBP-535990
G elongation factor, mitochondrial 2
IDBP-538192
G elongation factor, mitochondrial 2
IDBP-534487
G elongation factor, mitochondrial 2
IDBP-535633
G elongation factor, mitochondrial 2
IDBP-542110
G elongation factor, mitochondrial 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164347:
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at least three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:97137937-97181195
Strand Forward strand
Band D1
Transcripts
ENSMUST00000042084 ENSMUSP00000048373
ENSMUST00000022170 ENSMUSP00000022170
ENSMUST00000160139 ENSMUSP00000124426
ENSMUST00000161843
ENSMUST00000161639 ENSMUSP00000125656
ENSMUST00000161913 ENSMUSP00000124253
ENSMUST00000161518
ENSMUST00000161825 ENSMUSP00000125088
ENSMUST00000161929 ENSMUSP00000125306
ENSMUST00000160981 ENSMUSP00000125682
ENSMUST00000160989
ENSMUST00000159321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0032543 mitochondrial translation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164347
View Gene Order
ENSBTAG00000015519
Not yet available
Pathways
NETPATH
REACTOME
REACT_268789
Mitochondrial translation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_270158
Mitochondrial translation termination pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267602
Mitochondrial translation termination pathway
REACT_270450
Mitochondrial translation pathway
REACT_270960
Mitochondrial translation termination pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.219675
RefSeq NM_001146043 NM_001271463 NM_001271464 NM_001271465 NM_177266 XM_006517689 XM_006517690 XM_006517691
OMIM
CCDS CCDS26708 CCDS49338 CCDS70490 CCDS70491
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca