Version 5.4
Homo sapiens Gene: COQ7
Summary
InnateDB Gene IDBG-17528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COQ7
Gene Name coenzyme Q7 homolog, ubiquinone (yeast)
Synonyms CAT5; CLK-1; CLK1
Species Homo sapiens
Ensembl Gene ENSG00000167186
Encoded Proteins
IDBP-17530
coenzyme Q7 homolog, ubiquinone (yeast)
IDBP-603493
coenzyme Q7 homolog, ubiquinone (yeast)
IDBP-751113
IDBP-751223
IDBP-747877
IDBP-752778
IDBP-749280
IDBP-746891
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:19067599-19080095
Strand Forward strand
Band p12.3
Transcripts
ENST00000321998 ENSP00000322316
ENST00000544894 ENSP00000442923
ENST00000567314
ENST00000568985 ENSP00000456734
ENST00000566110 ENSP00000456943
ENST00000569127 ENSP00000455122
ENST00000569259
ENST00000569312 ENSP00000459076
ENST00000561858 ENSP00000457256
ENST00000566049 ENSP00000456490
ENST00000564746
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0001306 age-dependent response to oxidative stress
GO:0001701 in utero embryonic development
GO:0001841 neural tube formation
GO:0006744 ubiquinone biosynthetic process
GO:0006979 response to oxidative stress
GO:0008340 determination of adult lifespan
GO:0022008 neurogenesis
GO:0022904 respiratory electron transport chain
GO:0034599 cellular response to oxidative stress
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070584 mitochondrion morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030652
View Gene Order
ENSBTAG00000021242
Not yet available
Pathways
NETPATH
REACTOME
REACT_160111
Ubiquinol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00130
Ubiquinone and other terpenoid-quinone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BS11
UniProt Splice Variant
Entrez Gene 10229
UniGene Hs.157113 Hs.594975 Hs.664046
RefSeq NM_001190983 NM_016138 XM_005255033
HUGO HGNC:2244
OMIM 601683
CCDS CCDS10574 CCDS53993
HPRD 03401
IMGT
EMBL AC099518
GenPept
RNA Seq Atlas 10229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca