Version 5.4
Mus musculus Gene: Sp110
Summary
InnateDB Gene IDBG-175534.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sp110
Gene Name Sp110 nuclear body protein
Synonyms 5031415C07Rik; 52kDa; 5830484A20Rik; ENSMUSG00000075603; Ifi75; Ipr1
Species Mus musculus
Ensembl Gene ENSMUSG00000070034
Encoded Proteins
IDBP-175536
Sp110 nuclear body protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135899:
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:85576899-85598817
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000093508 ENSMUSP00000091226
ENSMUST00000128339
ENSMUST00000131950
ENSMUST00000143363
ENSMUST00000152399
ENSMUST00000151690
ENSMUST00000150114
ENSMUST00000130727
ENSMUST00000186740
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0009617 response to bacterium
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000135899
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.335802 Mm.441193 Mm.459416
RefSeq NM_030194 NM_175397 XM_006529066 XM_006529067 XM_006529068 XM_006529069
OMIM
CCDS CCDS35637
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca