InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gria1

Summary

InnateDB Gene

IDBG-175573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gria1

Gene Name

glutamate receptor, ionotropic, AMPA1 (alpha 1)

Synonyms

2900051M01Rik; Glr-1; Glr1; GluA1; Glur-1; GluR-A; gluR-K1; Glur1; GluRA; HIPA1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020524

Encoded Proteins

IDBP-175544

glutamate receptor, ionotropic, AMPA1 (alpha 1)

IDBP-175575

glutamate receptor, ionotropic, AMPA1 (alpha 1)

IDBP-625274

glutamate receptor, ionotropic, AMPA1 (alpha 1)

IDBP-538571

glutamate receptor, ionotropic, AMPA1 (alpha 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155511:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:57011387-57330244

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000094179	ENSMUSP00000091731
ENSMUST00000036315	ENSMUSP00000044494
ENSMUST00000125292	ENSMUSP00000133439
ENSMUST00000151045	ENSMUSP00000117746
ENSMUST00000173531

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007268	synaptic transmission
GO:0007616	long-term memory
GO:0031623	receptor internalization
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0008328	ionotropic glutamate receptor complex
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032590	dendrite membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0044308	axonal spine
GO:0044309	neuron spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane