Mus musculus Gene: Lrrk2
Summary
InnateDB Gene IDBG-175625.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Lrrk2
Gene Name leucine-rich repeat kinase 2
Synonyms 4921513O20Rik; 9330188B09Rik; AW561911; cI-46; D630001M17Rik; Gm927;
Species Mus musculus
Ensembl Gene ENSMUSG00000036273
Encoded Proteins
leucine-rich repeat kinase 2
Protein Structure
InnateDB Annotation
Summary
Lrrk2 acts as a potent negative regulator of the transcription factor NFAT, and plays an important role in modulating inflammatory bowel disease. Lrrk2 deficiency conferred enhanced susceptibility to experimental colitis in mice.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] LRRK2 acts as a potent negative regulator of the transcription factor NFAT, and plays an important role in modulating inflammatory bowel disease.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188906:
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:91673175-91816120
Strand Forward strand
Band E3
Transcripts
ENSMUST00000060642 ENSMUSP00000052584
ENSMUST00000140734
ENSMUST00000156900
ENSMUST00000133743
ENSMUST00000137657
ENSMUST00000172797
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 137 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0015631 tubulin binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0034211 GTP-dependent protein kinase activity
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007406 negative regulation of neuroblast proliferation
GO:0007528 neuromuscular junction development
GO:0008340 determination of adult lifespan
GO:0010508 positive regulation of autophagy
GO:0010942 positive regulation of cell death
GO:0014043 negative regulation of neuron maturation
GO:0015031 protein transport
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0021772 olfactory bulb development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034260 negative regulation of GTPase activity
GO:0035564 regulation of kidney size
GO:0035640 exploration behavior
GO:0040012 regulation of locomotion
GO:0042391 regulation of membrane potential
GO:0043068 positive regulation of programmed cell death
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
GO:0048312 intracellular distribution of mitochondria
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0070997 neuron death
GO:2000173 negative regulation of branching morphogenesis of a nerve
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0032473 external side of mitochondrial outer membrane
GO:0032839 dendrite cytoplasm
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045121 membrane raft
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Parkinson`s disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Parkinson`s disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q5S006
TrEMBL
UniProt Splice Variant
Entrez Gene 66725
UniGene Mm.37558 Mm.399181
RefSeq NM_025730
OMIM
CCDS CCDS37180
HPRD
IMGT
MGI ID 1913975 MGI:1913975
MGI Symbol Lrrk2
EMBL AC099704 AC158752 AK034413 AK052591 AY792512 BC034074 BC035949
GenPept AAH34074 AAH35949 AAV63976 BAC28700 BAC35052
ImmGen Lrrk2 (murine)
RNA Seq Atlas 66725