Version 5.4
Mus musculus Gene: Prdx2
Summary
InnateDB Gene IDBG-175630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prdx2
Gene Name peroxiredoxin 2
Synonyms AL022839; Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1; Torin; TPx; TPx-B; TR; TSA
Species Mus musculus
Ensembl Gene ENSMUSG00000005161
Encoded Proteins
IDBP-175632
peroxiredoxin 2
IDBP-261754
peroxiredoxin 2
IDBP-261756
peroxiredoxin 2
IDBP-539848
peroxiredoxin 2
IDBP-621145
peroxiredoxin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167815:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:84969587-84974834
Strand Forward strand
Band C3
Transcripts
ENSMUST00000005292 ENSMUSP00000005292
ENSMUST00000109734 ENSMUSP00000105356
ENSMUST00000109733 ENSMUSP00000105355
ENSMUST00000143402
ENSMUST00000138748
ENSMUST00000125893 ENSMUSP00000122694
ENSMUST00000127215
ENSMUST00000164807 ENSMUSP00000126451
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0008379 thioredoxin peroxidase activity
GO:0008430 selenium binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0002536 respiratory burst involved in inflammatory response
GO:0006979 response to oxidative stress
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0019430 removal of superoxide radicals
GO:0030194 positive regulation of blood coagulation
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0042098 T cell proliferation
GO:0042743 hydrogen peroxide metabolic process
GO:0042744 hydrogen peroxide catabolic process
GO:0045581 negative regulation of T cell differentiation
GO:0048538 thymus development
GO:0048872 homeostasis of number of cells
GO:0055114 oxidation-reduction process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167815
View Gene Order
ENSBTAG00000012062
Not yet available
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_206069
Cellular responses to stress pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z4A4
UniProt Splice Variant
Entrez Gene 21672
UniGene Mm.347009 Mm.389169
RefSeq NM_011563 XM_006530835
OMIM
CCDS CCDS40416
HPRD
IMGT
MGI ID MGI:109486
MGI Symbol Prdx2
EMBL AC163703
GenPept
RNA Seq Atlas 21672

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca