Version 5.4
Mus musculus Gene: Msh5
Summary
InnateDB Gene IDBG-175896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msh5
Gene Name mutS homolog 5 (E. coli)
Synonyms G7; Mut5
Species Mus musculus
Ensembl Gene ENSMUSG00000007035
Encoded Proteins
IDBP-175898
mutS homolog 5 (E. coli)
IDBP-175902
mutS homolog 5 (E. coli)
IDBP-627985
mutS homolog 5 (E. coli)
IDBP-627986
mutS homolog 5 (E. coli)
IDBP-627987
mutS homolog 5 (E. coli)
IDBP-627988
mutS homolog 5 (E. coli)
IDBP-627991
mutS homolog 5 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204410:
This locus represents naturally occurring read-through transcription between the neighboring mutS homolog 5 (MSH5) and chromosome 6 open reading frame 26 (C6orf26) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011] This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35028605-35046745
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000007250 ENSMUSP00000007250
ENSMUST00000097338 ENSMUSP00000094951
ENSMUST00000173124
ENSMUST00000174026 ENSMUSP00000134295
ENSMUST00000174603 ENSMUSP00000134065
ENSMUST00000172536 ENSMUSP00000134426
ENSMUST00000174556 ENSMUSP00000134061
ENSMUST00000173685
ENSMUST00000165329
ENSMUST00000174741
ENSMUST00000173928
ENSMUST00000172491 ENSMUSP00000133415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0030983 mismatched DNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006298 mismatch repair
GO:0007127 meiosis I
GO:0007129 synapsis
GO:0007131 reciprocal meiotic recombination
GO:0007292 female gamete generation
GO:0045143 homologous chromosome segregation
GO:0051026 chiasma assembly
Cellular Component
GO:0000795 synaptonemal complex
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204410
View Gene Order
ENSBTAG00000019790
Not yet available
Pathways
NETPATH
REACTOME
REACT_27235
Meiotic Recombination pathway
REACT_200794
Mus musculus biological processes pathway
REACT_188804
Cell Cycle pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24192
RefSeq NM_001146215 NM_013600 XM_006523770 XM_006523771 XM_006523772 XM_006523780 XM_006523781 XM_006523782 XM_006523785 XM_006525332 XM_006525333 XM_006525334 XM_006525342 XM_006525343 XM_006525344 XM_006525347 XM_006536555 XM_006536556 XM_006536557 XM_006536565 XM_006536566 XM_006536567 XM_006536570 XM_006537287 XM_006537288 XM_006537289 XM_006537297 XM_006537298 XM_006537299 XM_006537302
OMIM
CCDS CCDS28674
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca