Mus musculus Gene: G6pc2 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||
InnateDB Gene | IDBG-176067.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | G6pc2 | ||||||||
Gene Name | glucose-6-phosphatase, catalytic, 2 | ||||||||
Synonyms | G6pc-rs; IGRP | ||||||||
Species | Mus musculus | ||||||||
Ensembl Gene | ENSMUSG00000005232 | ||||||||
Encoded Proteins |
glucose-6-phosphatase, catalytic, 2
glucose-6-phosphatase, catalytic, 2
|
||||||||
Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
Entrez Gene | |||||||||
Summary |
This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
||||||||
Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 2:69211073-69227841 | ||||||||
Strand | Forward strand | ||||||||
Band | C2 | ||||||||
Transcripts |
|
||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
Gene Ontology | |||||||||
Molecular Function |
|
||||||||
Biological Process |
|
||||||||
Cellular Component |
|
||||||||
Orthologs | |||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||
Pathways | |||||||||
NETPATH | |||||||||
REACTOME |
Disease pathway
SLC-mediated transmembrane transport pathway
Metabolism pathway
Glucose transport pathway
Transmembrane transport of small molecules pathway
Hexose transport pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
|
||||||||
KEGG |
Insulin signaling pathway pathway
Glycolysis / Gluconeogenesis pathway
Starch and sucrose metabolism pathway
Galactose metabolism pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
|
||||||||
INOH | |||||||||
PID NCI | |||||||||
Pathway Predictions based on Human Orthology Data | |||||||||
NETPATH | |||||||||
REACTOME |
Glucose transport pathway
Hexose transport pathway
Transmembrane transport of small molecules pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
|
||||||||
KEGG |
Galactose metabolism pathway
Glycolysis / Gluconeogenesis pathway
Insulin signaling pathway pathway
Starch and sucrose metabolism pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
|
||||||||
INOH | |||||||||
PID NCI | |||||||||
Cross-References | |||||||||
SwissProt | Q9Z186 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 14378 | ||||||||
UniGene | Mm.140768 | ||||||||
RefSeq | NM_001289857 NM_021331 XM_006498754 | ||||||||
OMIM | |||||||||
CCDS | CCDS16089 CCDS71066 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
MGI ID | MGI:1277193 | ||||||||
MGI Symbol | G6pc2 | ||||||||
EMBL | AF118762 AF118763 AF118764 AF118765 AF118766 AK148465 AL929170 BC111905 Z47787 | ||||||||
GenPept | AAD28562 AAI11906 BAE28569 CAA87708 CAM24718 CAM24719 | ||||||||
RNA Seq Atlas | 14378 | ||||||||