Version 5.4
Homo sapiens Gene: OSMR
Summary
InnateDB Gene IDBG-17615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSMR
Gene Name oncostatin M receptor
Synonyms OSMRB; PLCA1
Species Homo sapiens
Ensembl Gene ENSG00000145623
Encoded Proteins
IDBP-17619
oncostatin M receptor
IDBP-478381
oncostatin M receptor
IDBP-475807
oncostatin M receptor
IDBP-474405
oncostatin M receptor
IDBP-476372
oncostatin M receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:38845858-38945596
Strand Forward strand
Band p13.1
Transcripts
ENST00000274276 ENSP00000274276
ENST00000502536 ENSP00000422023
ENST00000513831 ENSP00000423913
ENST00000509237 ENSP00000426729
ENST00000508882 ENSP00000422372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004924 oncostatin-M receptor activity
GO:0005515 protein binding
GO:0019838 growth factor binding
Biological Process
GO:0002675 positive regulation of acute inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0034097 response to cytokine
GO:0038165 oncostatin-M-mediated signaling pathway
Cellular Component
GO:0005900 oncostatin-M receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022146
View Gene Order
ENSBTAG00000033107
Not yet available
Pathways
NETPATH
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.120658 Hs.658389
RefSeq NM_001168355 NM_003999 XM_005248384 XM_005248385 XM_006714509
HUGO
OMIM
CCDS CCDS3928 CCDS54847
HPRD 03446
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca