Version 5.4
Mus musculus Gene: Ins1
Summary
InnateDB Gene IDBG-176189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ins1
Gene Name insulin I
Synonyms Ins-1; Ins2-rs1
Species Mus musculus
Ensembl Gene ENSMUSG00000035804
Encoded Proteins
IDBP-176191
insulin I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:52264323-52265456
Strand Forward strand
Band D2
Transcripts
ENSMUST00000039652 ENSMUSP00000049095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005158 insulin receptor binding
GO:0005179 hormone activity
GO:0051087 chaperone binding
Biological Process
GO:0006006 glucose metabolic process
GO:0010033 response to organic substance
GO:0015758 glucose transport
GO:0031018 endocrine pancreas development
GO:0034097 response to cytokine
GO:0043434 response to peptide hormone
GO:0051591 response to cAMP
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030141 secretory granule
GO:0034774 secretory granule lumen
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_246380
SHC activation pathway
REACT_189085
Disease pathway
REACT_252337
SHC-related events pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_217323
Integration of energy metabolism pathway
REACT_198563
Amyloids pathway
REACT_244029
Signal attenuation pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_233293
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_261478
IRS activation pathway
REACT_214529
Regulation of gene expression in beta cells pathway
REACT_188576
Developmental Biology pathway
REACT_205507
Regulation of beta-cell development pathway
REACT_243154
IRS-related events pathway
REACT_233181
Insulin receptor recycling pathway
REACT_188257
Signal Transduction pathway
REACT_207837
Insulin processing pathway
KEGG
mmu04950
Maturity onset diabetes of the young pathway
mmu04940
Type I diabetes mellitus pathway
mmu04930
Type II diabetes mellitus pathway
mmu04140
Regulation of autophagy pathway
mmu04910
Insulin signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04150
mTOR signaling pathway pathway
mmu05215
Prostate cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
mmu04114
Oocyte meiosis pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.46269
RefSeq NM_008386
OMIM
CCDS CCDS29898
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca