InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itsn1

Summary

InnateDB Gene

IDBG-176668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itsn1

Gene Name

intersectin 1 (SH3 domain protein 1A)

Synonyms

AA517634; AA545208; AI316805; AI839402; AI848451; Ehsh1; Ese1; Itsn; Sh3p17

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022957

Encoded Proteins

IDBP-176670

intersectin 1 (SH3 domain protein 1A)

IDBP-176674

intersectin 1 (SH3 domain protein 1A)

IDBP-176678

intersectin 1 (SH3 domain protein 1A)

IDBP-252659

intersectin 1 (SH3 domain protein 1A)

IDBP-252661

intersectin 1 (SH3 domain protein 1A)

IDBP-252663

intersectin 1 (SH3 domain protein 1A)

IDBP-252665

intersectin 1 (SH3 domain protein 1A)

IDBP-252667

intersectin 1 (SH3 domain protein 1A)

IDBP-538293

intersectin 1 (SH3 domain protein 1A)

IDBP-538456

intersectin 1 (SH3 domain protein 1A)

IDBP-536417

intersectin 1 (SH3 domain protein 1A)

IDBP-542369

intersectin 1 (SH3 domain protein 1A)

IDBP-532017

intersectin 1 (SH3 domain protein 1A)

IDBP-538774

intersectin 1 (SH3 domain protein 1A)

IDBP-542376

intersectin 1 (SH3 domain protein 1A)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205726:
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:91729281-91920597

Strand

Forward strand

Band

Transcripts

ENSMUST00000095909	ENSMUSP00000093598
ENSMUST00000056482	ENSMUSP00000056011
ENSMUST00000064797	ENSMUSP00000066361
ENSMUST00000114002	ENSMUSP00000109635
ENSMUST00000114001	ENSMUSP00000109634
ENSMUST00000113999	ENSMUSP00000109632
ENSMUST00000113996	ENSMUSP00000109629
ENSMUST00000113993	ENSMUSP00000109626
ENSMUST00000139890
ENSMUST00000131983
ENSMUST00000135057	ENSMUSP00000117018
ENSMUST00000133389
ENSMUST00000124094
ENSMUST00000156841
ENSMUST00000151044
ENSMUST00000144101
ENSMUST00000154967
ENSMUST00000153741	ENSMUSP00000117320
ENSMUST00000143023	ENSMUSP00000119654
ENSMUST00000126374	ENSMUSP00000114718
ENSMUST00000138117
ENSMUST00000141073
ENSMUST00000125052	ENSMUSP00000115985
ENSMUST00000131739	ENSMUSP00000114145
ENSMUST00000141625	ENSMUSP00000115563
ENSMUST00000137575

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019209	kinase activator activity
GO:0032947	protein complex scaffold
GO:0070064	proline-rich region binding

Biological Process

GO:0006897	endocytosis
GO:0007264	small GTPase mediated signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0043524	negative regulation of neuron apoptotic process
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030139	endocytic vesicle
GO:0043005	neuron projection
GO:0045202	synapse