InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mknk1

Summary

InnateDB Gene

IDBG-176847.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mknk1

Gene Name

MAP kinase-interacting serine/threonine kinase 1

Synonyms

2410048M24Rik; Mnk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028708

Encoded Proteins

IDBP-176849

MAP kinase-interacting serine/threonine kinase 1

IDBP-268599

MAP kinase-interacting serine/threonine kinase 1

IDBP-539985

MAP kinase-interacting serine/threonine kinase 1

IDBP-533802

MAP kinase-interacting serine/threonine kinase 1

IDBP-537590

MAP kinase-interacting serine/threonine kinase 1

IDBP-542099

MAP kinase-interacting serine/threonine kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21149447

Mknk1 plays an important role in Ifng induced Irf1 expression and is essential for generation of anti-proliferation responses.

InnateDB Annotation from Orthologs

Summary

PMID 21149447

[Homo sapiens] MKNK1 plays an important role in IFNG induced IRF1 expression and is essential for generation of anti-proliferative responses.

Entrez Gene

Summary

This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:115839198-115879250

Strand

Forward strand

Band

Transcripts

ENSMUST00000019677	ENSMUSP00000019677
ENSMUST00000106513	ENSMUSP00000102123
ENSMUST00000144235
ENSMUST00000144427	ENSMUSP00000117261
ENSMUST00000153766
ENSMUST00000155412
ENSMUST00000130819	ENSMUSP00000118071
ENSMUST00000151203	ENSMUSP00000114941
ENSMUST00000140315	ENSMUSP00000116410
ENSMUST00000140585
ENSMUST00000152888
ENSMUST00000150201
ENSMUST00000154957
ENSMUST00000135209

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006417	regulation of translation
GO:0006446	regulation of translational initiation
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009651	response to salt stress
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand