Version 5.4
Mus musculus Gene: Ncl
Summary
InnateDB Gene IDBG-176947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ncl
Gene Name nucleolin
Synonyms B530004O11Rik; C23; D0Nds28; D1Nds28; Nucl
Species Mus musculus
Ensembl Gene ENSMUSG00000026234
Encoded Proteins
IDBP-176949
nucleolin
IDBP-790093
nucleolin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115053:
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86344719-86359400
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000027438 ENSMUSP00000027438
ENSMUST00000185676
ENSMUST00000188682
ENSMUST00000186050
ENSMUST00000189504
ENSMUST00000185785 ENSMUSP00000140696
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 159 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 159 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042162 telomeric DNA binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001525 angiogenesis
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115053
View Gene Order
ENSBTAG00000016174
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
myc_activpathway
Validated targets of C-MYC transcriptional activation
aurora_b_pathway
Aurora B signaling
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 17975
UniGene
RefSeq NM_010880
OMIM
CCDS CCDS35646
HPRD
IMGT
MGI ID MGI:97286
MGI Symbol Ncl
EMBL
GenPept
RNA Seq Atlas 17975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca