Version 5.4
Mus musculus Gene: Aif1
Summary
InnateDB Gene IDBG-177226.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aif1
Gene Name allograft inflammatory factor 1
Synonyms AI607846; AIF-1; D17H6S50E; G1; Iba1
Species Mus musculus
Ensembl Gene ENSMUSG00000024397
Encoded Proteins
IDBP-177228
allograft inflammatory factor 1
IDBP-628136
allograft inflammatory factor 1
IDBP-628137
allograft inflammatory factor 1
IDBP-628138
allograft inflammatory factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204472:
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35170991-35176068
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000025257 ENSMUSP00000025257
ENSMUST00000173281
ENSMUST00000172693 ENSMUSP00000134214
ENSMUST00000173324 ENSMUSP00000133709
ENSMUST00000172679
ENSMUST00000173106 ENSMUSP00000134107
ENSMUST00000174044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0006911 phagocytosis, engulfment
GO:0006954 inflammatory response
GO:0010629 negative regulation of gene expression
GO:0014739 positive regulation of muscle hyperplasia
GO:0016601 Rac protein signal transduction
GO:0030041 actin filament polymerization
GO:0030335 positive regulation of cell migration
GO:0031668 cellular response to extracellular stimulus
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0042102 positive regulation of T cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048678 response to axon injury
GO:0051017 actin filament bundle assembly
GO:0051602 response to electrical stimulus
GO:0071315 cellular response to morphine
GO:0071346 cellular response to interferon-gamma
GO:0071447 cellular response to hydroperoxide
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0071673 positive regulation of smooth muscle cell chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis
GO:0097178 ruffle assembly
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204472
View Gene Order
ENSBTAG00000020554
Not yet available
Cross-References
SwissProt O70200
TrEMBL A1E2H8 Q4FJL9 Q7TSW1
UniProt Splice Variant
Entrez Gene 11629
UniGene Mm.10747
RefSeq NM_019467 XM_006523504 XM_006525278 XM_006536503 XM_006537236 XM_006523502 XM_006525276 XM_006536501 XM_006537234
OMIM
CCDS CCDS28689
HPRD
IMGT
MGI ID MGI:1343098
MGI Symbol Aif1
EMBL AB013745 AB036423 AF074959 AF109719 AJ560665 AK006184 AK006562 BC021539 CH466666 CT010265 CT010385 D86382 EF101555 U82792
GenPept AAC24189 AAC25604 AAC82481 AAH21539 ABK96804 BAA28216 BAA86387 BAB20758 BAB24445 BAB24654 CAD91187 CAJ18473 CAJ18592 EDL26636 EDL26637
RNA Seq Atlas 11629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca