Version 5.4
Mus musculus Gene: Siglece
Summary
InnateDB Gene IDBG-177258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siglece
Gene Name sialic acid binding Ig-like lectin E
Synonyms Cd170; mSiglec-E; Siglec12; Siglec5; Siglec9; Siglecl1
Species Mus musculus
Ensembl Gene ENSMUSG00000030474
Encoded Proteins
IDBP-177260
sialic acid binding Ig-like lectin E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19933851
Siglece is upregulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production and help maintain a healthy cytokine balance following infection.
PMID 21208791
Siglece is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:43651070-43660161
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000032667 ENSMUSP00000032667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0048029 monosaccharide binding
Biological Process
GO:0007155 cell adhesion
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q91Y57
TrEMBL
UniProt Splice Variant
Entrez Gene 83382
UniGene Mm.157702
RefSeq NM_031181
OMIM
CCDS CCDS21178
HPRD
IMGT
MGI ID MGI:1932475
MGI Symbol Siglece
EMBL AC151989 AF317298 AF329269
GenPept AAG38598 AAK49917
RNA Seq Atlas 83382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca