InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Phkb

Summary

InnateDB Gene

IDBG-177530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phkb

Gene Name

phosphorylase kinase beta

Synonyms

AI463271

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036879

Encoded Proteins

IDBP-177532

phosphorylase kinase beta

IDBP-535908

phosphorylase kinase beta

IDBP-533636

phosphorylase kinase beta

IDBP-536366

phosphorylase kinase beta

IDBP-540564

phosphorylase kinase beta

IDBP-532612

phosphorylase kinase beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102893:
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:85840959-86061376

Strand

Forward strand

Band

Transcripts

ENSMUST00000053771	ENSMUSP00000050788
ENSMUST00000159716
ENSMUST00000160611	ENSMUSP00000125690
ENSMUST00000159882
ENSMUST00000161850	ENSMUSP00000124939
ENSMUST00000162464	ENSMUSP00000125197
ENSMUST00000162981	ENSMUSP00000124522
ENSMUST00000160731	ENSMUSP00000125051
ENSMUST00000162305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004689	phosphorylase kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding