InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc4a4

Summary

InnateDB Gene

IDBG-177669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc4a4

Gene Name

solute carrier family 4 (anion exchanger), member 4

Synonyms

AI835705; NBC; NBC1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060961

Encoded Proteins

IDBP-254347

solute carrier family 4 (anion exchanger), member 4

IDBP-254349

solute carrier family 4 (anion exchanger), member 4

IDBP-532534

solute carrier family 4 (anion exchanger), member 4

IDBP-539506

solute carrier family 4 (anion exchanger), member 4

IDBP-533931

solute carrier family 4 (anion exchanger), member 4

IDBP-532710

solute carrier family 4 (anion exchanger), member 4

IDBP-535810

solute carrier family 4 (anion exchanger), member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080493:
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:88886818-89239653

Strand

Forward strand

Band

Transcripts

ENSMUST00000113218	ENSMUSP00000108844
ENSMUST00000113216	ENSMUSP00000108842
ENSMUST00000148750	ENSMUSP00000119325
ENSMUST00000135283
ENSMUST00000156238	ENSMUSP00000121744
ENSMUST00000144713	ENSMUSP00000122975
ENSMUST00000130041	ENSMUSP00000118413
ENSMUST00000134303	ENSMUSP00000119976

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0005515	protein binding
GO:0008509	anion transmembrane transporter activity
GO:0008510	sodium:bicarbonate symporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006820	anion transport
GO:0006885	regulation of pH
GO:0015701	bicarbonate transport
GO:0035725	sodium ion transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome