Version 5.4
Mus musculus Gene: Chrng
Summary
InnateDB Gene IDBG-177828.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chrng
Gene Name cholinergic receptor, nicotinic, gamma polypeptide
Synonyms Achr-3; Acrg
Species Mus musculus
Ensembl Gene ENSMUSG00000026253
Encoded Proteins
IDBP-177830
cholinergic receptor, nicotinic, gamma polypeptide
IDBP-790306
cholinergic receptor, nicotinic, gamma polypeptide
IDBP-790307
cholinergic receptor, nicotinic, gamma polypeptide
IDBP-790309
cholinergic receptor, nicotinic, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196811:
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:87204657-87212694
Strand Forward strand
Band C5
Transcripts
ENSMUST00000027470 ENSMUSP00000027470
ENSMUST00000185763 ENSMUSP00000139600
ENSMUST00000188796 ENSMUSP00000140796
ENSMUST00000186038 ENSMUSP00000141001
ENSMUST00000189392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196811
View Gene Order
ENSBTAG00000045943
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_22149
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_22223
Highly sodium permeable acetylcholine nicotinic receptors pathway
REACT_22126
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_22336
Presynaptic nicotinic acetylcholine receptors pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_15461
Acetylcholine Binding And Downstream Events pathway
REACT_217102
Presynaptic nicotinic acetylcholine receptors pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_208574
Highly sodium permeable acetylcholine nicotinic receptors pathway
REACT_225032
Neuronal System pathway
REACT_202849
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_226667
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_214962
Acetylcholine Binding And Downstream Events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VQK4
UniProt Splice Variant
Entrez Gene 11449
UniGene Mm.2810
RefSeq NM_009604 XM_006529078
OMIM
CCDS CCDS35651
HPRD
IMGT
MGI ID MGI:87895
MGI Symbol Chrng
EMBL AC102611
GenPept
RNA Seq Atlas 11449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca