InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gad1

Summary

InnateDB Gene

IDBG-177867.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gad1

Gene Name

glutamate decarboxylase 1

Synonyms

EP10; Gad-1; GAD25; GAD44; GAD67

Species

Mus musculus

Ensembl Gene

ENSMUSG00000070880

Encoded Proteins

IDBP-177869

glutamic acid decarboxylase 1

IDBP-534275

glutamic acid decarboxylase 1

IDBP-537065

glutamic acid decarboxylase 1

IDBP-533532

glutamic acid decarboxylase 1

IDBP-534225

glutamic acid decarboxylase 1

IDBP-538012

glutamic acid decarboxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128683:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:70553072-70602014

Strand

Forward strand

Band

Transcripts

ENSMUST00000094934	ENSMUSP00000092539
ENSMUST00000130618	ENSMUSP00000117521
ENSMUST00000130604	ENSMUSP00000117721
ENSMUST00000155979
ENSMUST00000148210	ENSMUSP00000119733
ENSMUST00000130998	ENSMUSP00000119379
ENSMUST00000123330	ENSMUSP00000116301
ENSMUST00000140478

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004351	glutamate decarboxylase activity
GO:0016595	glutamate binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0008152	metabolic process
GO:0009449	gamma-aminobutyric acid biosynthetic process
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042493	response to drug

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005938	cell cortex
GO:0030424	axon
GO:0043679	axon terminus
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048786	presynaptic active zone