InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGFR1

Summary

InnateDB Gene

IDBG-17796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGFR1

Gene Name

fibroblast growth factor receptor 1

Synonyms

bFGF-R-1; BFGFR; CD331; CEK; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD

Species

Homo sapiens

Ensembl Gene

ENSG00000077782

Encoded Proteins

IDBP-17781

fibroblast growth factor receptor 1

IDBP-17800

fibroblast growth factor receptor 1

IDBP-17802

fibroblast growth factor receptor 1

IDBP-17806

fibroblast growth factor receptor 1

IDBP-236018

fibroblast growth factor receptor 1

IDBP-236020

fibroblast growth factor receptor 1

IDBP-236022

fibroblast growth factor receptor 1

IDBP-236024

fibroblast growth factor receptor 1

IDBP-367568

fibroblast growth factor receptor 1

IDBP-367609

fibroblast growth factor receptor 1

IDBP-367610

fibroblast growth factor receptor 1

IDBP-367616

fibroblast growth factor receptor 1

IDBP-367620

fibroblast growth factor receptor 1

IDBP-602573

fibroblast growth factor receptor 1

IDBP-596957

fibroblast growth factor receptor 1

IDBP-590945

fibroblast growth factor receptor 1

IDBP-596491

fibroblast growth factor receptor 1

IDBP-594528

fibroblast growth factor receptor 1

IDBP-602507

fibroblast growth factor receptor 1

IDBP-601875

fibroblast growth factor receptor 1

IDBP-598599

fibroblast growth factor receptor 1

IDBP-599274

fibroblast growth factor receptor 1

IDBP-812371

fibroblast growth factor receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:38411138-38468834

Strand

Reverse strand

Band

p11.23

Transcripts

ENST00000341462	ENSP00000340636
ENST00000326324	ENSP00000327229
ENST00000335922	ENSP00000337247
ENST00000356207	ENSP00000348537
ENST00000397113	ENSP00000380302
ENST00000397108	ENSP00000380297
ENST00000397103	ENSP00000380292
ENST00000397091	ENSP00000380280
ENST00000397090
ENST00000447712	ENSP00000400162
ENST00000425967	ENSP00000393312
ENST00000434187	ENSP00000392645
ENST00000413133	ENSP00000400708
ENST00000440174	ENSP00000398318
ENST00000487647	ENSP00000435254
ENST00000466021
ENST00000475621
ENST00000464163
ENST00000470826
ENST00000496296
ENST00000474970
ENST00000484370	ENSP00000433163
ENST00000496629
ENST00000480571
ENST00000533619
ENST00000527114
ENST00000527745
ENST00000524528
ENST00000530701
ENST00000526570
ENST00000531196	ENSP00000434800
ENST00000532791	ENSP00000432972
ENST00000526688
ENST00000527203
ENST00000533668	ENSP00000434869
ENST00000525001	ENSP00000434712
ENST00000532386
ENST00000526742	ENSP00000433569
ENST00000529552	ENSP00000435283
ENST00000530568	ENSP00000434473
ENST00000619564	ENSP00000484553

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	80 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008201	heparin binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001501	skeletal system development
GO:0001525	angiogenesis
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001759	organ induction
GO:0001764	neuron migration
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007435	salivary gland morphogenesis
GO:0007605	sensory perception of sound
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0010518	positive regulation of phospholipase activity
GO:0010629	negative regulation of gene expression
GO:0010863	positive regulation of phospholipase C activity
GO:0010976	positive regulation of neuron projection development
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021769	orbitofrontal cortex development
GO:0021847	ventricular zone neuroblast division
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030901	midbrain development
GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042472	inner ear morphogenesis
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0043009	chordate embryonic development
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response
GO:0045595	regulation of cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045787	positive regulation of cell cycle
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048339	paraxial mesoderm development
GO:0048378	regulation of lateral mesodermal cell fate specification
GO:0048469	cell maturation
GO:0048514	blood vessel morphogenesis
GO:0048699	generation of neurons
GO:0048705	skeletal system morphogenesis
GO:0048762	mesenchymal cell differentiation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060117	auditory receptor cell development
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060484	lung-associated mesenchyme development
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043235	receptor complex