Version 5.4
Mus musculus Gene: Ptprn2
Summary
InnateDB Gene IDBG-178037.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprn2
Gene Name protein tyrosine phosphatase, receptor type, N polypeptide 2
Synonyms 4930425H11Rik; IA2beta; mKIAA0387; phogrin; Phol; PTP-NP
Species Mus musculus
Ensembl Gene ENSMUSG00000056553
Encoded Proteins
IDBP-178041
protein tyrosine phosphatase, receptor type, N polypeptide 2
IDBP-789257
protein tyrosine phosphatase, receptor type, N polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155093:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:116485720-117276849
Strand Forward strand
Band F2
Transcripts
ENSMUST00000070733 ENSMUSP00000064046
ENSMUST00000185505
ENSMUST00000189009
ENSMUST00000190247 ENSMUSP00000139978
ENSMUST00000191106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0034260 negative regulation of GTPase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0016021 integral component of membrane
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0043195 terminal bouton
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000155093
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04940
Type I diabetes mellitus pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04940
Type I diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011215
OMIM
CCDS CCDS36576
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca