InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ocln

Summary

InnateDB Gene

IDBG-178074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ocln

Gene Name

occludin

Synonyms

AI503564; Ocl

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021638

Encoded Proteins

IDBP-178076

occludin

IDBP-178078

occludin

IDBP-537851

occludin

IDBP-541796

occludin

IDBP-542488

occludin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197822:
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:100496507-100552718

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022140	ENSMUSP00000022140
ENSMUST00000069756	ENSMUSP00000065284
ENSMUST00000159459	ENSMUSP00000125642
ENSMUST00000160859	ENSMUSP00000124849
ENSMUST00000159515	ENSMUSP00000125595

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008119	thiopurine S-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0019904	protein domain specific binding

Biological Process

GO:0032259	methylation
GO:0045216	cell-cell junction organization
GO:0046498	S-adenosylhomocysteine metabolic process
GO:0046500	S-adenosylmethionine metabolic process
GO:0070830	tight junction assembly

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030054	cell junction
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000197822

View Gene Order

ENSBTAG00000000561

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04530

Tight junction pathway

mmu04514

Cell adhesion molecules (CAMs) pathway

mmu04670

Leukocyte transendothelial migration pathway

mmu05160

Hepatitis C pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13579

Apoptotic cleavage of cell adhesion proteins pathway

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

KEGG

hsa05130

Pathogenic Escherichia coli infection pathway

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa05160

Hepatitis C pathway

INOH

PID NCI

tgfbrpathway

TGF-beta receptor signaling

Cross-References

SwissProt

TrEMBL

E0CZ91

UniProt Splice Variant

Entrez Gene

18260

UniGene

Mm.4807

RefSeq

NM_008756 XM_006517563 XM_006517564 XM_006517565 XM_006517566

OMIM

CCDS

CCDS26731

HPRD

IMGT

MGI ID

MGI:106183

MGI Symbol

Ocln

EMBL

AC158536

GenPept

RNA Seq Atlas

18260