Version 5.4
Mus musculus Gene: Tbxa2r
Summary
InnateDB Gene IDBG-178084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbxa2r
Gene Name thromboxane A2 receptor
Synonyms TP; TXA2-R
Species Mus musculus
Ensembl Gene ENSMUSG00000034881
Encoded Proteins
IDBP-271114
thromboxane A2 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:81328732-81335171
Strand Forward strand
Band C1
Transcripts
ENSMUST00000105325 ENSMUSP00000100962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004960 thromboxane receptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0019229 regulation of vasoconstriction
GO:0019932 second-messenger-mediated signaling
GO:0032496 response to lipopolysaccharide
GO:0042493 response to drug
GO:0045766 positive regulation of angiogenesis
GO:0045777 positive regulation of blood pressure
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006638
View Gene Order
ENSBTAG00000014944
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_230556
Prostanoid ligand receptors pathway
REACT_233922
Thromboxane signalling through TP receptor pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_231468
GPCR ligand binding pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_253164
Eicosanoid ligand-binding receptors pathway
REACT_251507
Signal amplification pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_18425
Prostanoid ligand receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_20524
Signal amplification pathway
REACT_604
Hemostasis pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_205369
Signaling by GPCR pathway
REACT_213855
Eicosanoid ligand-binding receptors pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_214353
Signal Transduction pathway
REACT_222735
Signal amplification pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_217614
Prostanoid ligand receptors pathway
REACT_214436
GPCR downstream signaling pathway
REACT_210152
Thromboxane signalling through TP receptor pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_205384
G alpha (12/13) signalling events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
Cross-References
SwissProt P30987
TrEMBL Q5FW61 Q712P5 Q712P6
UniProt Splice Variant
Entrez Gene 21390
UniGene
RefSeq NM_001277265 NM_009325 XM_006513460
OMIM
CCDS CCDS24053
HPRD
IMGT
MGI ID MGI:98496
MGI Symbol Tbxa2r
EMBL AB115920 AJ009969 AJ009970 AK158477 BC089611 BC138885 BC138886 CH466553 D10849
GenPept AAH89611 AAI38886 AAI38887 BAA01622 BAE34532 BAF82013 CAA08920 CAA08921 EDL31427
RNA Seq Atlas 21390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca