Version 5.4
Mus musculus Gene: Habp2
Summary
InnateDB Gene IDBG-178182.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Habp2
Gene Name hyaluronic acid binding protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025075
Encoded Proteins
IDBP-178184
hyaluronic acid binding protein 2
IDBP-178186
hyaluronic acid binding protein 2
IDBP-622451
hyaluronic acid binding protein 2
IDBP-622453
hyaluronic acid binding protein 2
IDBP-622455
hyaluronic acid binding protein 2
IDBP-622457
hyaluronic acid binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148702:
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:56287137-56320822
Strand Forward strand
Band D2
Transcripts
ENSMUST00000078284 ENSMUSP00000077402
ENSMUST00000095948 ENSMUSP00000093641
ENSMUST00000165407
ENSMUST00000171341 ENSMUSP00000126235
ENSMUST00000166049 ENSMUSP00000132444
ENSMUST00000163502 ENSMUSP00000128964
ENSMUST00000165522 ENSMUSP00000130809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148702
View Gene Order
ENSBTAG00000019322
Not yet available
Cross-References
SwissProt Q8K0D2
TrEMBL E9Q092 E9Q0C5 E9QM92 F7B276 F7D2A6 Q3V1J8
UniProt Splice Variant
Entrez Gene 226243
UniGene Mm.25791
RefSeq NM_146101 XM_006527014 XM_006527016 XM_006527017
OMIM
CCDS CCDS50475
HPRD
IMGT
MGI ID MGI:1196378
MGI Symbol Habp2
EMBL AC115771 AC161579 AK132407 BC031775
GenPept AAH31775 BAE21152
RNA Seq Atlas 226243

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca