Version 5.4
Mus musculus Gene: Ngef
Summary
InnateDB Gene IDBG-178471.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ngef
Gene Name neuronal guanine nucleotide exchange factor
Synonyms ephexin; Tims2
Species Mus musculus
Ensembl Gene ENSMUSG00000026259
Encoded Proteins
IDBP-178473
neuronal guanine nucleotide exchange factor
IDBP-178475
neuronal guanine nucleotide exchange factor
IDBP-627867
neuronal guanine nucleotide exchange factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066248:
Gene Information
Type Protein coding
Genomic Location Chromosome 1:87476834-87573870
Strand Reverse strand
Band D
Transcripts
ENSMUST00000027477 ENSMUSP00000027477
ENSMUST00000068681 ENSMUSP00000066894
ENSMUST00000168235 ENSMUSP00000127674
ENSMUST00000166463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0009987 cellular process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043087 regulation of GTPase activity
GO:0048013 ephrin receptor signaling pathway
GO:0061002 negative regulation of dendritic spine morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030426 growth cone
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000066248
View Gene Order
ENSBTAG00000008942
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_261444
Axon guidance pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
epha_fwdpathway
EPHA forward signaling
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.435439
RefSeq NM_001111314 NM_019867
OMIM
CCDS CCDS48306 CCDS48307
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca