InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Afp

Summary

InnateDB Gene

IDBG-178564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Afp

Gene Name

alpha fetoprotein

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054932

Encoded Proteins

IDBP-178566

alpha fetoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081051:
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:90490714-90508907

Strand

Forward strand

Band

Transcripts

ENSMUST00000042755

ENSMUSP00000041006

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0006810	transport
GO:0019953	sexual reproduction
GO:0042448	progesterone metabolic process
GO:0060395	SMAD protein signal transduction

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000081051

View Gene Order

ENSBTAG00000017131

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

p53downstreampathway

Direct p53 effectors

reg_gr_pathway

Glucocorticoid receptor regulatory network

p73pathway

p73 transcription factor network

Cross-References

SwissProt

P02772

TrEMBL

Q3TGA3

UniProt Splice Variant

Entrez Gene

11576

UniGene

Mm.358570 Mm.398486

RefSeq

NM_007423

OMIM

CCDS

CCDS19413

HPRD

IMGT

MGI ID

MGI:87951

MGI Symbol

Afp

EMBL

AK010934 AK145975 AK146513 AK146524 AK167549 AK168574 AK168576 AK168751 AK168818 AK168883 AK169046 AK169054 AK169147 BC066206 M16381 M16382 M16383 M16384 M16385 M16386 M16387 M16388 M16389 M16390 M16391 M16392 M16393 M16394 V00743

GenPept

AAA37189 AAH66206 BAB27278 BAE26798 BAE27225 BAE27233 BAE39615 BAE40444 BAE40446 BAE40591 BAE40645 BAE40701 BAE40834 BAE40842 BAE40926 CAA24118

RNA Seq Atlas

11576