InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atg16l1

Summary

InnateDB Gene

IDBG-178701.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atg16l1

Gene Name

autophagy related 16-like 1 (S. cerevisiae)

Synonyms

1500009K01Rik; Apg16l; Atg16l; WDR30

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026289

Encoded Proteins

IDBP-178703

autophagy-related 16-like 1 (yeast)

IDBP-254404

autophagy-related 16-like 1 (yeast)

IDBP-254408

autophagy-related 16-like 1 (yeast)

IDBP-534619

autophagy-related 16-like 1 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19898471

[Homo sapiens] ATG16L1 is involved in autophagy where it is recruited to the plasma membrane at the site of bacterial entry by NOD1 and NOD2.

PMID 20200479

[Homo sapiens] ATG16L1, a critical autophagy protein, is recruited to the plasma membrane by NOD2 during bacterial invasion.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085978:
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:87755870-87792428

Strand

Forward strand

Band

Transcripts

ENSMUST00000027512	ENSMUSP00000027512
ENSMUST00000113190	ENSMUSP00000108815
ENSMUST00000113186	ENSMUSP00000108811
ENSMUST00000144047	ENSMUSP00000120955
ENSMUST00000133072
ENSMUST00000137638
ENSMUST00000151037
ENSMUST00000134603
ENSMUST00000129431
ENSMUST00000139628
ENSMUST00000127884

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0015031	protein transport
GO:0039689	negative stranded viral RNA replication

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005776	autophagic vacuole
GO:0005930	axoneme
GO:0034045	pre-autophagosomal structure membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000085978

View Gene Order

ENSBTAG00000003928

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04140

Regulation of autophagy pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04140

Regulation of autophagy pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.410937

RefSeq

NM_001205391 NM_001205392 NM_029846

OMIM

CCDS

CCDS15136 CCDS56637 CCDS56638

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas