Version 5.4
Mus musculus Gene: Cxcl5
Summary
InnateDB Gene IDBG-178768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl5
Gene Name chemokine (C-X-C motif) ligand 5
Synonyms AMCF-II; ENA-78; GCP-2; LIX; Scyb5; Scyb6
Species Mus musculus
Ensembl Gene ENSMUSG00000029371
Encoded Proteins
IDBP-178770
chemokine (C-X-C motif) ligand 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25692402
Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.
Entrez Gene
Summary This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:90759299-90761625
Strand Forward strand
Band E1
Transcripts
ENSMUST00000031318 ENSMUSP00000031318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0001776 leukocyte homeostasis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0032496 response to lipopolysaccharide
GO:0032642 regulation of chemokine production
GO:0045087 innate immune response (InnateDB)
GO:0060326 cell chemotaxis
GO:0070951 regulation of neutrophil mediated killing of gram-negative bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_230248
Chemokine receptors bind chemokines pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P50228
TrEMBL
UniProt Splice Variant
Entrez Gene 20311
UniGene Mm.420795 Mm.4660
RefSeq NM_009141
OMIM
CCDS CCDS19414
HPRD
IMGT
MGI ID MGI:1096868
MGI Symbol Cxcl5
EMBL AC105995 AY100019 BC024392 U27267
GenPept AAC52238 AAH24392 AAM48589
RNA Seq Atlas 20311

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca