InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WASF3

Summary

InnateDB Gene

IDBG-17879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASF3

Gene Name

WAS protein family, member 3

Synonyms

Brush-1; SCAR3; WAVE3

Species

Homo sapiens

Ensembl Gene

ENSG00000132970

Encoded Proteins

IDBP-17883

WAS protein family, member 3

IDBP-17885

WAS protein family, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:26557703-26688948

Strand

Forward strand

Band

q12.13

Transcripts

ENST00000361042	ENSP00000354325
ENST00000335327	ENSP00000335055
ENST00000496788

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding

Biological Process

GO:0006461	protein complex assembly
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0014003	oligodendrocyte development
GO:0030032	lamellipodium assembly
GO:0030041	actin filament polymerization
GO:0031643	positive regulation of myelination

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030027	lamellipodium

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029636

View Gene Order

ENSBTAG00000014619

Not yet available

Pathways

NETPATH

REACTOME

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_12529

Signaling by VEGF pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_6900

Immune System pathway

REACT_228166

VEGFA-VEGFR2 Pathway pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

KEGG

hsa04520

Adherens junction pathway

hsa04666

Fc gamma R-mediated phagocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

Q9UPY6

TrEMBL

B4DGR1 Q5T8P4

UniProt Splice Variant

Entrez Gene

10810

UniGene

Hs.618732 Hs.731015 Hs.737259

RefSeq

NM_001291965 NM_006646 XM_005266239

HUGO

HGNC:12734

OMIM

605068

CCDS

CCDS9318

HPRD

IMGT

EMBL

AB020707 AB026543 AF134305 AF454702 AK289845 AK294725 AL159978 AL163538 AL353789 BC050283 CH471075

GenPept

AAD33054 AAH50283 AAL51032 BAA74923 BAA81796 BAF82534 BAG57872 CAH72487 EAX08388 EAX08389

RNA Seq Atlas

10810