Version 5.4
Mus musculus Gene: Pf4
Summary
InnateDB Gene IDBG-178816.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pf4
Gene Name platelet factor 4
Synonyms Cxcl4; Scyb4
Species Mus musculus
Ensembl Gene ENSMUSG00000029373
Encoded Proteins
IDBP-178818
platelet factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163737:
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:90772435-90773381
Strand Forward strand
Band E1
Transcripts
ENSMUST00000031320 ENSMUSP00000031320
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0006461 protein complex assembly
GO:0006955 immune response
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0030595 leukocyte chemotaxis
GO:0030816 positive regulation of cAMP metabolic process
GO:0042127 regulation of cell proliferation
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031091 platelet alpha granule
GO:0031982 vesicle
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000163737
View Gene Order
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_223625
GPCR downstream signaling pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_230248
Chemokine receptors bind chemokines pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_259461
Common Pathway pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04062
Chemokine signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_1439
Common Pathway pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_604
Hemostasis pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt Q9Z126
TrEMBL Q3TVN6
UniProt Splice Variant
Entrez Gene 56744
UniGene
RefSeq NM_019932
OMIM
CCDS CCDS19416
HPRD
IMGT
MGI ID MGI:1888711
MGI Symbol Pf4
EMBL AB017491 AF349465 AK159278 AK160040 CH466617
GenPept AAK30163 BAA75660 BAE34956 BAE35582 EDL05306
RNA Seq Atlas 56744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca