Version 5.4
Mus musculus Gene: Ddr1
Summary
InnateDB Gene IDBG-178873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddr1
Gene Name discoidin domain receptor family, member 1
Synonyms 6030432F18; AI323681; Cak; CD167a; Nep; PTK3A
Species Mus musculus
Ensembl Gene ENSMUSG00000003534
Encoded Proteins
IDBP-178875
discoidin domain receptor family, member 1
IDBP-178879
discoidin domain receptor family, member 1
IDBP-400960
discoidin domain receptor family, member 1
IDBP-400959
discoidin domain receptor family, member 1
IDBP-536829
discoidin domain receptor family, member 1
IDBP-628271
discoidin domain receptor family, member 1
IDBP-542323
discoidin domain receptor family, member 1
IDBP-540092
discoidin domain receptor family, member 1
IDBP-536863
discoidin domain receptor family, member 1
IDBP-538718
discoidin domain receptor family, member 1
IDBP-532990
discoidin domain receptor family, member 1
IDBP-628272
discoidin domain receptor family, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204580:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35681567-35704621
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000003628 ENSMUSP00000003628
ENSMUST00000097333 ENSMUSP00000094945
ENSMUST00000117301 ENSMUSP00000112570
ENSMUST00000119825 ENSMUSP00000113062
ENSMUST00000155957 ENSMUSP00000117427
ENSMUST00000155628 ENSMUSP00000133659
ENSMUST00000148065 ENSMUSP00000120635
ENSMUST00000134995 ENSMUSP00000117301
ENSMUST00000146472 ENSMUSP00000119397
ENSMUST00000145900 ENSMUSP00000122361
ENSMUST00000135078 ENSMUSP00000122191
ENSMUST00000166980 ENSMUSP00000133047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0038062 protein tyrosine kinase collagen receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0001558 regulation of cell growth
GO:0001952 regulation of cell-matrix adhesion
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007566 embryo implantation
GO:0007595 lactation
GO:0008285 negative regulation of cell proliferation
GO:0010715 regulation of extracellular matrix disassembly
GO:0014909 smooth muscle cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043583 ear development
GO:0044319 wound healing, spreading of cells
GO:0046777 protein autophosphorylation
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060749 mammary gland alveolus development
GO:0061302 smooth muscle cell-matrix adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204580
View Gene Order
ENSBTAG00000010682
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.398503 Mm.5021
RefSeq NM_001198831 NM_001198833 NM_007584 NM_172962 XM_006523533 XM_006523534 XM_006523535 XM_006523536 XM_006523537 XM_006523538
OMIM
CCDS CCDS28703 CCDS37603
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca